Resveratrol regulates skeletal muscle fibers switching through the AdipoR1-AMPK-PGC-1α pathway
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چکیده
منابع مشابه
THE EFFECTS OF INTERVAL TRAINING INTENSITY ON SKELETAL MUSCLE PGC-1Α IN TYPE2 DIABETIC MALE RATS
Background: The purpose of this study was to compare the effects of a 12 weeks interval training with high and moderate intensity on PGC-1α of skeletal muscle in type 2 diabetic male rats. Methods: 40 male rats were divided into two groups: High fat diet (HFD) (n=32) and standard diet (C) (n=8) for 10 weeks. After inducing type2 diabetes via STZ, 8 diabetic rats (D) and 8 rats in group C rats ...
متن کاملTime since menopause and skeletal muscle estrogen receptors, PGC-1α, and AMPK
OBJECTIVE Short-term administration of estradiol (E2) improves insulin-stimulated glucose disposal rate in early postmenopausal (EPM) women compared with a reduction in late postmenopausal (LPM) women. The underlying mechanisms by which E2 action on glucose disposal rate reversed from beneficial early to harmful late in menopause is unknown, but might include adverse changes in estrogen recepto...
متن کاملDiet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
SIRT3 is a member of the sirtuin family of NAD(+)-dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active tissues. We report here that SIRT3 responds dynamically to both exercise and nutritional signals in skeletal muscle to coordinate downstream molecular responses. We show that exercise training incr...
متن کاملPGC-1β regulates angiogenesis in skeletal muscle.
Aerobic metabolism requires oxygen and carbon sources brought to tissues via the vasculature. Metabolically active tissues such as skeletal muscle can regulate blood vessel density to match metabolic needs; however, the molecular cues that coordinate these processes remain poorly understood. Here we report that the transcriptional coactivator peroxisome proliferator-activated receptor-γ coactiv...
متن کاملHypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation injury through AMPK/eNOS/PGC-1α signaling pathway.
OBJECTIVE AMP-activated protein kinase (AMPK) is an important regulator of multiple cellular pathways in the setting of energetic stress. Whether AMPK plays a critical role in hypoxic preconditioning (HPC), protecting cardiomyocytes against hypoxia reoxygenation (H/R) injury remains uncertain. METHODS H9c2 cells were preconditioned by exposing to 10 min of hypoxia and 30 min of reoxygenation....
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ژورنال
عنوان ژورنال: Food & Function
سال: 2019
ISSN: 2042-6496,2042-650X
DOI: 10.1039/c8fo02518e